Deterministic chaos in the self-assembly of β sheet nanotubes from an amphipathic oligopeptide.

Fengbin Wang, Ordy Gnewou, Shengyuan Wang, Tomasz Osinski, Xiaobing Zuo, Edward H Egelman, Vincent P Conticello


The self-assembly of designed peptides into filaments and other higher-order structures has been the focus of intense interest because of the potential for creating new biomaterials and biomedical devices. These peptide assemblies have also been used as models for understanding biological processes, such as the pathological formation of amyloid. We investigate the assembly of an octapeptide sequence, Ac-FKFEFKFE-NH